BCVR The 5thJCS Council Forum on Basic Cardio Vascular Research

第5回日本循環器学会基礎研究フォーラム
病因の真実に迫る 飽くなき挑戦

Program

The 5th JCS Council Forum on Basic CardioVascular Research (BCVR 2021) is a Web conference.

<Web conference> September 11th (Sat.) - 12(Sun.), 2021

Plenary Lecture, Keynote Lecture, Special Lecture, Symposium, Progress Report for Basic Research, Grant Session in Basic Research, Luncheon Seminar, Award Session, Abstract Session



September 11th (Sat.)

Opening remarks

September 11th (Sat.) 9:00-9:10

Naoki Mochizuki
Chairperson
The 5th JCS Council Forum on Basic CardioVascular Research (BCVR2021)
Director General, National Cerebral and Cardiovascular Center Research Institute

Welcome remarks
Kinya Otsu
President,National Cerebral and Cardiovascular Center

Symposium 1

September 11th (Sat.) 9:15-10:35

Tissue regeneration and rejuvenation
Chairperson:
Masaki Ieda
Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan
Kazu Kikuchi
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Japan
Speaker:
Cardiac vasculature during development and injury repair
Kristy Red-Horse
Department of Biology, Stanford University, USA
Klf1-induced mechanisms for adult cardiomyocyte renewal
Kazu Kikuchi
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Japan


Senolysis: a potential therapeutic target for anti-aging
Makoto Nakanishi
Division of Cancer Cell Biology, Institute of Medical Science,University of Tokyo, Japan

Sponsord by: KANEKA CORPORATION

Symposium 2

September 11th (Sat.) 10:50-12:10

Bioenergetics
Chairperson:
Satoaki Matoba
Department of Cardiovascular Medicine, Graduate School of Medical Science,Kyoto Prefectural University of Medicine, Japan
Yasunori Shintani
Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center, Japan
Speaker:

Roles of mitochondrial dynamics in health and disease
Naotada Ishihara
Department of Biological Sciences, Graduate School of Science,Osaka University, Japan


Arf1/PI(4)KIII β -generated PI(4)P drives mitochondrial division
Shun Nagashima
Tokyo University of Pharmacy and Life Sciences, Japan


Imaging of ATP dynamics inside living and dying cells
Hiromi Imamura
Graduate School of Biostudies, Kyoto University, Japan

Luncheon Seminar&Break S-1,3,4,5

September 11th (Sat.) 12:40-13:25

Luncheon Seminar
S-1


PDF

New concept of salt and significance for MR inhibition
Chairperson: 坂田 泰史 先生 (大阪大学大学院医学系研究科 循環器内科学)
Speaker: 西山 成 先生 (香川大学医学部 薬理学)
Sponsord by: 第一三共株式会社 DAIICHI SANKYO COMPANY, LIMITED
Luncheon Seminar
S-3


PDF

Biology of LipoQuality: Advanced lipidomics technology and its application in biology
Chairperson: 室原 豊明 先生 (名古屋大学大学院医学系研究科 循環器内科学)
Speaker: 有田 誠 先生 (慶應義塾大学薬学部 代謝生理化学講座 )
Sponsord by: 武田薬品工業株式会社 Takeda Pharmaceutical Company Limited
Luncheon Seminar
S-4


PDF

Molecular Pathogenesis and Treatment Strategy of Takayasu Arteritis
Chairperson: 大谷 朋仁 先生 (大阪大学大学院医学系研究科 循環器内科学)
Speaker: 中岡 良和 先生 (国立循環器病研究センター研究所 血管生理学部)
Sponsord by: 中外製薬株式会社 CHUGAI PHARMACEUTICAL CO., LTD.
Luncheon Seminar
S-5


PDF

Exploring Novel Therapeutic Strategies toward PAH : Perspectives from Pediatric Cardiology
Chairperson: 瀧原 圭子 先生 (大阪大学キャンパスライフ健康支援センター)
Speaker: 三谷 義英 先生 (三重大学医学部付属病院)
Sponsord by: ヤンセンファーマ株式会社 メディカルアフェアーズ本部 Janssen Pharmaceutical K.K.

Symposium 3

September 11th (Sat.) 13:30-14:50

Cardiovascular development and disease
Chairperson:
Hiroki Kurihara
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Japan
Osamu Nakagawa
Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Japan
Speaker:
A new regulator of lymphatic vascular growth and proliferation in early development from zebrafish genetics
Benjamin Hogan
Peter MacCallum Cancer Centre, Department of Anatomy and Physiology, University of Melbourne, Australia

4D imaging and quantitative analysis of tissue deformation and collective cell motion during initial heart looping
Yoshihiro Morishita
RIKEN Center for Biosystems Dynamics Research, Japan


Diversity within the neural crest lineage contributing cardiac development revealed by transcriptomic analysis
Hiroki Kurihara
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Japan

Progress Report for Basic Research

September 11th (Sat.) 14:55-15:55

Chairperson:
Yasushi Sakata
Department of Cardiovascular Medicine Osaka University Graduate School of Medicine, Japan
Yasuko K. Bando
Department of Cardiology, Nagoya University Graduate School of Medicine,Japan
Speaker:

Exploring drug candidates for LMNA -mutant dilated cardiomyopathy
Masamichi Ito
Department of Cardiovascular Disease, Graduate School of Medicine,the University of Tokyo, Japan

Imprication of Hormonal and Mechanical Regulation in Maturation of Cardiomyocytes Derived from Pluripotent Stem Cells.
Hideki Uosaki
Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Japan

Anti-inflammatory approach targeting calcium/calmodulin-dependent protein kinase II delta
as a novel therapeutic strategy to the heart failure

Takeshi Suetomi
Division of Cardiology, Department of Medicine and Clinical Sciences, Yamaguchi University Graduate School of Medicine, Japan

The analysis of dynamic brain chages responding to heart stress
Junichi Sugita
The University of Tokyo, Japan

Impact of gut microbial LPS on cardiovascular diseases
Naofumi Yoshida
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan

Keynote Lecture 1

September 11th (Sat.) 16:00-16:40

A Vegfc-Emilin2a-Cxcl8a signaling axis required for zebrafish cardiac regeneration
Chairperson: 
Issei Komuro
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan

Speaker:
Didier Stainier
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Germany

Plenary Lecture

September 11th (Sat.) 16:45-17:35

Cardiac progenitor cells of the Second Heart Field - from 2001 to 2021
Chairperson: 
Ichiro Shiojima
Department of Medicine Ⅱ, Kansai Medical University, Japan

Speaker:
Margaret Buckingham
Department of Developmental and Stem Cell Biology, Pasteur Institute, France

Special Lecture

September 11th (Sat.) 17:40-18:40

Explore the possibilities
Chairperson:
Naoki Mochizuki
National Cerebral and Cardiovascular Center Research Institute, Japan

Speaker:
Tadao Ando
Architect / Distinguished Professor, The University of Tokyo

September 12th (Sun.)

Grant Session in Basic Research

September 12th (Sun.) 9:00-10:00

Chairperson: 
Koji Maemura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Ken-ichi Hirata
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Speaker:

Gut microbiota dependent monopoiesis induced by high fat diet is a target for cardiovascular diseases.
Takuo Emoto
Division of Cardiovascular Medicine, Department of Internal Medicine,Kobe University School of Medicine, Japan

Investigation of the mechanism of microvessel remodeling in pulmonary hypertension using spatiotemporal multi-scale imaging system
Takayuki Fujiwara
The University of Tokyo Hospital, Japan

Cell fate conversion by epigenome editing
Hisayuki Hashimoto
Keio University School of Medicine, Japan

Elucidation of the molecular mechanism underlying amyloid fibril deposition in ATTR amyloidosis
Hidenori Moriyama
Department of Cardiology, Keio University School of Medicine,Japan

RNF213-associated vascular disease; a novel concept unifying various vasculopathies
Takahiro Hiraide
Keio University School of Medicine, Japan

Symposium 4

September 12th (Sun.)10:05-11:25

Microbiome and Cardiovascular Diseases
Chairperson:
Ken-ichi Hirata
Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan
Yoshikazu Nakaoka
Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Japan
Speaker:

Mining the gut microbiota and identifying effector microbes that causally affect the host physiology
Kenya Honda
Department of Microbiology and Immunology, Keio University School of Medicine, Japan


Aryl hydrocarbon receptor and gut microbiome in the pathogenesis of pulmonary arterial hypertension
Yoshikazu Nakaoka
Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Japan


Microbiome and Coronary Artery Disease
Tomoya Yamashita
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan

Keynote Lecture 2

September 12th (Sun.)11:30-12:10

Remote injury responses during zebrafish heart regeneration
Chairperson:
Toyoaki Murohara
Department of Cardiology, Nagoya University Graduate School of Medicine, Japan

Speaker:
Kenneth Poss
Duke Regeneration Center and Department of Cell Biology, Duke University School of Medicine, USA

Luncheon Seminar&Break C-1,2,3,4,5

September 12th (Sun.)12:20-13:05

Luncheon Seminar
C-1
Development of Artificial Intelligence (AI)-Analysis of Wearable Cardiac Monitor for the Detection of Subclinical Arrhythmias
Chairperson: 佐久間 一郎 先生 (東京大学工学系研究科)
Speaker: 草野 研吾 先生 (国立循環器病研究センター 心臓血管内科・不整脈科)
Sponsord by: JSR株式会社 JSR Corporation
Luncheon Seminar
C-2


PDF

Shall we draw PV loop?
Chairperson: 朔 啓太 先生 (国立循環器病研究センター 循環動態制御部)
Speaker: 假屋 太郎 先生 (東京大学医学部附属病院 麻酔科)
犬塚 亮 先生 (東京大学医学部附属病院 小児科)
Sponsord by: 大正医科器械株式会社 Taisho Biomed Instruments Co., Ltd.
Luncheon Seminar
C-3


PDF

Treatment of dyslipidemia to prevent cardiovascular events
Chairperson: 平田 健一 先生 (神戸大学大学院医学研究科・内科学講座 循環器内科学分野)
Speaker: 佐田 政隆 先生 (徳島大学大学院医歯薬学研究部 循環器内科学)
Sponsord by: 武田薬品工業株式会社 Takeda Pharmaceutical Company Limited

Luncheon Seminar
C-4


PDF

Novel Development of cGMP Therapies for Heart Failure:
Lessons from VICTORIA Study

Chairperson: 彦惣 俊吾 先生 (大阪大学 大学院医学系研究科循環器内科学)
Speaker: 中川 仁 先生 (奈良県立医科大学 循環器内科)
Sponsord by: バイエル薬品株式会社 Bayer Yakuhin, Ltd.

Luncheon Seminar
C-5
Machine learning technology for cardiovascular research
Chairperson: 桑原 宏一郎 先生 (信州大学 循環器内科)
Speaker: 湯浅 慎介 先生 (慶応義塾大学 循環器内科)
Sponsord by: トーアエイヨー株式会社 TOA EIYO LTD.

Symposium 5

September 12th (Sun.)13:10-14:30

Multi-layer Cardiovascular Simulation ~Science based development and Application~
Chairperson:
Koichiro Kinugawa
The Second Department of Internal Medicine, University of Toyama, Japan
Kenya Kusunose
Department of Cardiovascular Medicine, Tokushima University Hospital,Japan
Speaker :

Development of the world’s most popular CV simulator:“ Harvi”
Daniel Burkhoff
Cardiovascular Research Foundation, USA

Multi-scale, multi-physics heart simulator‘ UT-Heart’ for basic and clinical researches in cardiology
Seiryo Sugiura
UT-Heart Inc., Japan

Topological Definition of Vortex Flow Structures inside the Left Ventricle
Keiichi Itatani
Department of Cardiovascular Surgery, Osaka City University, Japan

Development of hemodynamics visualizing simulator“ SimArthur”
Keita Saku
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Japan

Precision Cardiology and Bio Digital Twin Creation
Joe Alexander
Medical and Health Informatics Laboratories, NTT Research, Inc., USA

Sponsord by: Neuroceuticals Inc.

Abstract Session Short presentation

September 12th (Sun.)14:40-16:20

1: Vasucular biology
2: Genomics and Regeneration
3: Heart failure
4: Inflammation and Cell signaling
5: Metabolism

Award Session

September 12th (Sun.)16:30-17:20

Chairperson:
Yoshihiko Saito
Department of Cardiovascular Medicine, Nara Medical University, Japan
Satoaki Matoba
Department of Cardiovascular Medicine, Graduate School of Medical Science,Kyoto Prefectural University of Medicine, Japan
Speaker:

PGC-1a mediated angiogenesis ameliorates pulmonary hypertension in mice
Takayuki Fujiwara
Department of Cardiovascular Medicine, the University of Tokyo Hospital, Center for Molecular Medicine, Jichi Medical University

Keap1-NRF2 pathway attenuates fibroblast activation
Toshiyuki Nishiji
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine

Endogenous ketone body ameliorate the pathogenesis of obesity related heart failure with preserved ejection fraction.
Toshihiro Yamada
Kumamoto University

Identification of a novel origin of endothelial cells in zebrafish
Hiroyuki Nakajima
National Cerebral and Cardiovascular Center Research Institute

The role of endoplasmic reticulum (ER)-selective autophagy in response to ER stress-mediated myocardial injury
Shun Nakagama
Tokyo Medical and Dental University

Closing remarks

September 12th (Sun.)17:20-17:30

Naoki Mochizuki
Chairperson
The 5th JCS Council Forum on Basic CardioVascular Research (BCVR2021)
Director General, National Cerebral and Cardiovascular Center Research Institute

Ichiro Shiojima
Chairperson
The 6th JCS Council Forum on Basic CardioVascular Research (BCVR2022)
Professor, Department of Medicine Ⅱ, Kansai Medical University

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